Abstract: Taking the strong motion records of Yangbi Station obtained by the May 21, 2021 M6.4 Yunnan Yangbi earthquake as input, this study performed dynamic time history analysis on frame structures of different heights and a low-rise brick-concrete structure. Based on this, we explore the response characteristics of the frame structure in the strong earthquake, compare the difference between the seismic response of the brick-concrete structure and low-rise frame structure, and evaluate the performance of the brick-concrete structure. The main analysis results show that the vertical acceleration amplification effect is significant in the floor acceleration response to all structures, especially in the lower frame. The peak value of the floor Fourier amplitude spectrum for the frame is mainly in the frequency range of 1~2.5 Hz in Y direction. Compared with the low-rise and high-rise, the maximum inter-story drift ratios response of the multi-story frame is greater. The inter-story drift ratios of all structures do not exceed the medium damage limit. Compared with the low-rise frame structure, the brick-concrete structure of a shorter basic period has a more significant horizontal acceleration amplification effect to the floor. The fortified brick-concrete structure has good aseismic performance. The analysis results can provide reference for the analysis and evaluation of earthquake damage of buildings after strong earthquake.