Abstract: With its high-precision detection capability, deep seismic reflection profiling has become a pioneering technique for investigating the fine structure of the lithosphere and has been widely used in numerous global deep exploration projects. The original time-domain profile only reflects seismic wave traveltime and cannot directly and accurately recover the true subsurface geometry and depths of geological interfaces. Therefore, achieving the transformation from the time domain to the depth domain based on a velocity model and accurately depicting subsurface structural morphology using depth-domain imaging results are key steps in enhancing the Earth-imaging capability of deep seismic reflection profiles. In this paper, we systematically summarize the development of deep seismic reflection profile depth-domain imaging technology, focusing on the application and effectiveness of pre-stack depth migration in deep seismic reflection profile depth-domain imaging through domestic and international examples from typical continental deep seismic reflection profiles such as the Tibetan Plateau, the Bohai Bay Basin and the western Eger rift in central Europe. This study can provide critical technical support for the exploration of fine crustal structures in continental regions and serve as a reference for understanding the deep crustal dynamics and evolution.