Abstract: On September 18, 2024, the M_S4.7 earthquake occurred in Hefei, Anhui Province, causing certain building damage and social panic. This was the largest earthquake of magnitude to occur in the Hefei area in 2024. In today's highly developed self-media, the social attention caused by minor destructive earthquakes in the eastern coastal regions remains high, especially the earthquake in the southern section of the Tanlu earthquake zone, where several small earthquakes of around M_S3.0 have occurred recently. What if the magnitude of this earthquake is not M_S4.7 but M_S6.0? With the significant improvement of China's earthquake monitoring capabilities, the waveform data of this earthquake can be recorded relatively completely. The empirical Green's function method can use small earthquake waveforms as Green's functions to synthesize the seismic motion of large earthquakes, and this M_S4.7 earthquake happens to meet the criteria for selecting small earthquakes as Green's functions in this method. This article intends to use the M_S4.7 earthquake as Green's function and the empirical Green's function method as the simulation tool to quickly estimate the acceleration waveform of a set M_S6.0 earthquake at seven stations in the Hefei area from the perspective of earthquake emergency and analyze the seismic damage response and destructive capacity of this set earthquake in a determined building model. The results indicate that if the magnitude of this earthquake is M_S6.0, it will demonstrate strong destructive power in the Feidong area, with PGA values ranging from 0.25–0.6 g within a distance of 30 km from the epicenter. There is a risk of serious damage to the building, especially for old and high-rise buildings in the area. This study attempts to estimate the characteristics of strong earthquake ground motion and analyze building damage from the perspective of earthquake emergency response. The relevant results can also provide a reference for local seismic design and earthquake emergency products.